Comparing E421 - Mannitol vs E951 - Aspartame
Overview
Synonyms
Products
Found in 571 products
Found in 3,750 products
Search rank & volume
Awareness score
Search volume over time
Interest over time for 2 keywords in U.S. during the last 10 years.
Interest over time for 12 keywords in U.S. during the last 10 years.
Popular questions
What is mannitol used for?
In foods, E421 mannitol is used as a low‑calorie sweetener, bulking agent, and humectant/stabilizer (common in sugar‑free gum, candies, and baked goods); it’s also a pharmaceutical excipient. Medically, IV mannitol is an osmotic diuretic to reduce intracranial and intraocular pressure and promote diuresis.
How mannitol works?
As a food ingredient, it’s poorly absorbed so it provides fewer calories and a low glycemic response, with a mild cooling taste. As a medicine, it acts osmotically—filtered by the kidneys and minimally reabsorbed—raising plasma and tubular fluid osmolality to draw water from tissues and increase urine output, lowering brain/eye pressure.
How does mannitol work?
It works osmotically when given IV, increasing blood and renal filtrate osmolality so water moves from tissues into the circulation and then into urine, reducing intracranial and intraocular pressure. In foods, its limited absorption yields a lower-calorie, low‑glycemic sweetening effect.
Is mannitol safe for dogs?
Mannitol isn’t known to be acutely toxic to dogs like xylitol, but ingestion can cause diarrhea and gas, and large amounts may lead to dehydration or electrolyte imbalances. Therapeutic IV mannitol should only be used by a veterinarian; consult your vet especially for dogs with kidney or heart disease.
Is mannitol salt agar selective or differential?
Both: the high salt concentration makes it selective for staphylococci, and mannitol with phenol red makes it differential by turning yellow when mannitol‑fermenting organisms (e.g., many S. aureus) produce acid.
Is aspartame bad for you?
For most people, no—regulators like EFSA, FDA, and WHO/JECFA consider aspartame safe at typical intakes within the acceptable daily intake (about 40–50 mg/kg body weight/day). People with phenylketonuria (PKU) must avoid it because it provides phenylalanine.
Does aspartame cause cancer?
Current evidence does not show a cancer risk at typical dietary exposures; EFSA, FDA, and WHO/JECFA have maintained its ADI and found it safe at current intakes. IARC classified it as “possibly carcinogenic” (Group 2B) in 2023 based on limited evidence, which did not change regulatory safety conclusions.
Does coke zero have aspartame?
Yes—Coca‑Cola Zero Sugar in many countries contains aspartame (often with acesulfame K); formulas can vary by market, so check your local label.
Why is aspartame bad for you?
It isn’t generally “bad” at normal food levels; the key exception is for people with PKU, who must avoid the phenylalanine it provides. Some individuals report sensitivities (e.g., headaches), so staying within the ADI is advised.
Does aspartame raise blood sugar?
No—aspartame does not raise blood glucose or insulin on its own and is considered suitable for people with diabetes within the ADI. Other ingredients in the food or drink may still affect blood sugar.